Monday, March 24, 2014

PART A: ESH/ESC GUIDELINES FOR MANAGEMENT OF ARTERIAL HYPERTENSION, OUTLINE

11:11 AM



Definitions and classification of office blood pressure levels (mmHg)


Systolic (mm Hg)

Diastolic (mm Hg)
Optimal

<120
             and
<80
Normal

       121-129
             and/or
80-84
High normal

       130-139
             and/or
85-89
Grade 1 Hypertension

       140-159
             and/or
90-99
Grade 2 Hypertension

       160-179
             and/or
 100-109
Grade 3 Hypertension

       ≥ 180
             and/or
≥110
Isolated Systolic Hypertension*

      ≥ 140
             and
<90
*Isolated systolic hypertension should be graded 1, 2, or 3 according to systolic BP values in the ranges indicated.
*     Worldwide, 1.5 billion people currently have high blood pressure, according to the World Health Organization.
*     Hypertension is defined as values ≥140 mmHg SBP and/or ≥90 mmHg DBP, based on the evidence from RCTs that in patients with these BP values treatment-induced BP reductions are beneficial.
*     Prompt initiation of drug treatment is recommended in individuals with grade 2 and 3 hypertension with any level of CV risk, a few weeks after or simultaneously with initiation of lifestyle changes.
*     Lowering BP with drugs is also recommended when total CV risk is high because of OD, diabetes, CVD or CKD, even when hypertension is in the grade 1 range.
*     Unless the necessary evidence is obtained it is not recommended to initiate antihypertensive drug therapy at high normal BP.
*     According to the new guidelines of  European Society of Hypertension (ESH) and the European Society of Cardiology (ESC) for the management of hypertension, simplifying treatment decisions for physicians with the recommendation that all patients be treated to <140 mm Hg systolic blood pressure.
A DBP target of <90 mmHg is always recommended.
*     The new guidelines do make exceptions for special populations, such as those with diabetes and the elderly. For those with diabetes, the ESH/ESC writing committee recommend that physicians treat patients to <85 mm Hg (80-85 mm Hg) diastolic blood pressure.
*     Lack of evidence does also not allow recommending to initiate antihypertensive drug therapy in young individuals withisolated elevation of brachial SBP, but these individuals should be followed closely with lifestyle recommendations.
*     Blood pressures exceeding 140/90 mm Hg increase the risk of cardiovascular disease and stroke. The Systematic Coronary Risk Evaluation (SCORE) known as heart score model has been developed to         estimates the risk of dying from CV (not just coronary) disease over 10 years based on age, gender, smoking habits, total cholesterol and SBP.
*     A SBP of ≥210 mmHg for men and ≥190 mmHg for women has been termed ‘exercise hypertension’ in a number of studies. In the case of normal resting BP,exercise-induced hypertension can be considered an indication for ABPM because of its association with masked hypertension.
*     It is recommended that the diagnosis of hypertension be based on at least two BPmeasurements per visit and on at least two visits. On at least one occasion, BP needs to be measured at both arms and differences between the two arms in SBP >20 mmHg and/or in DBP > 10 mmHg—if confirmed—should trigger further investigations of vascular abnormalities.



Definitions of hypertension by office & out-of-office blood pressure levels


  Systolic
(mm Hg)

Diastolic (mm Hg)
Office BP

       140
             and
90
Ambulatory BP




      Daytime(or awake)

135
             and/or
85
      Nighttime(or asleep )

120
             and/or
70
      24 hour

130
             and/or
80
Home BP

≥ 135
             and/or
≥85






*     Role of out of office B.P (ambulatory or home blood-pressure monitoring):
*       2013 guidelines are the first to consider out-of-office blood-pressure monitoring which provides a large number of measurements outside the medical environment which represents a more reliable assessment of actual BP than office BP. Out-of-office BP is commonly assessed by ABPM or HBPM usually by self-measurement.
*       ABPM:Patient wearing a portable BP measuring device, usually on the non-dominant arm, for a 24-25 h period, so that it gives information on BP during daily activities and at night during sleep.
*       HBPM: BP should be measured daily on at least 3 – 4 days and preferably on 7 consecutive days; in the mornings as well as in the evenings.

 Source: 


Dr.Qurat-ul-Ain Hafeez, Pharm-D, RPh.
Ambulatory Care Pharmacist, Aga khan University Hospital, Karachi , Pakistan
Facebook: Qurat Hafeez




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